Product Overview: Coleus Forskohlii Extract
Coleus forskohlii (scientific name: Coleus forskohlii (Willd.) Briq.) belongs to the genus Coleus of the Lamiaceae family, which is an erect or ascending herbaceous plant. Its stems are stout, about 40 cm tall, with obtuse 4-angled stems and 4 grooves, branched, covered with spreading villous hairs, and densely hairy at the top.
Coleus Forskohlii Extract is an aqueous or alcoholic extract derived from Coleus forskohlii, with forskolin as the key index active ingredient. It has multiple medicinal effects such as cardiotonic, hypotensive, and antispasmodic. In addition, Coleus forskohlii contains three forskolin analogs: isoforskolin, deacetylforskolin, and 1-acetyl-forskolin. These analogs have the activity of activating cyclic AMP (cAMP) in vitro and can reduce intraocular pressure to varying degrees, enriching the comprehensive efficacy of the extract.
Core Functions & Efficacy of Coleus Forskohlii Extract
1. Powerful Antiasthmatic & Antispasmodic Effects
Coleus Forskohlii Extract has significant antiasthmatic and antispasmodic effects. Its antispasmodic potency is as high as 145 times that of aminophylline, while its toxicity is far lower than that of aminophylline. This high-efficiency and low-toxicity characteristic makes it an ideal natural raw material for the development of antiasthmatic and antispasmodic products, which can effectively relieve respiratory spasms and asthma symptoms.
2. Dose-Dependent Hypotensive Effect
Key components in Coleus Forskohlii Extract, such as 1-acetoxyforskolin and isoforskolin, have been proven to reduce blood pressure in anesthetized rats in a dose-dependent manner, without causing significant changes in heart rate and other important physiological parameters. The hypotensive mechanism may be related to the fact that isoforskolin can directly activate adenylate cyclase and increase the level of cAMP in platelets, while also inhibiting ADP-induced platelet aggregation, providing dual protection for cardiovascular health.
3. Significant Antitumor Activity
Coleus Forskohlii Extract exhibits remarkable antitumor activity. It can significantly increase the activity of adenylate cyclase and promote the accumulation of cAMP. Maintaining an appropriate level of cAMP in the body can effectively regulate cell proliferation and differentiation, inhibit the abnormal proliferation of tumor cells, and thus exert an antitumor effect, providing a potential natural auxiliary raw material for tumor prevention and treatment research.
Why Choose Our Coleus Forskohlii Extract?
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High-Quality Raw Materials: Selected from high-quality Coleus forskohlii plants from authentic producing areas, with standardized planting and harvesting processes to ensure rich content of forskolin and other core active components.
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Controlled Active Ingredients: Takes forskolin as the key index component, with strictly controlled content, and retains natural forskolin analogs (isoforskolin, deacetylforskolin, etc.), ensuring comprehensive and stable efficacy.
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High Efficiency & Low Toxicity: The antispasmodic effect is far superior to that of traditional aminophylline, while the toxicity is significantly lower, meeting the high safety requirements of health products and pharmaceutical raw materials.
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Multi-Functional Advantages: Integrates antiasthmatic, antispasmodic, hypotensive and antitumor effects, covering multiple high-demand health fields such as respiratory and cardiovascular health, with broad application prospects.
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Wide Application Versatility: Suitable for raw materials of pharmaceutical preparations (antiasthmatic, hypotensive drugs), health care products, and functional foods, and can be processed into various formulations such as tablets, capsules, and oral liquids, meeting diverse production needs of B-end manufacturers.
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Strict Quality Control: Implements full-process quality inspection from raw material selection, extraction, purification to finished product delivery, strictly detecting active ingredient content, purity and impurities, ensuring consistent quality and safety of each batch.
Application Scenarios
Widely applied in the formulation of antiasthmatic and antispasmodic pharmaceutical preparations, hypotensive health care products, cardiovascular protective functional foods, and auxiliary antitumor nutritional supplements. It fully meets the production needs of pharmaceutical companies, health product factories, and food processing enterprises, as well as the health maintenance needs of individual consumers—especially those with asthma, hypertension, and cardiovascular health concerns.
