Introduction Of Coleus Forskohlii Extract
The Coleus forskohlii (Coleus forskohlii (Willd.) Briq.) is a family of lip-shaped flowers of the genus Coleoptera, which are erect or ascending herbaceous plant. Herbs erect or ascending. Stems stout, ca. 40 cm tall, obtuse 4-angled, 4-grooved, branched, spreading villous, densely distally.
The Coleus forskohlii extract is an aqueous or alcoholic extract of Coleus forskohlii, and the index active ingredient is forskolin. With cardiac, blood pressure, spasmolysis and other effects.
Isoforskolin, Deacetylforskolin and 1-acetyl-forskolin, the three forskolin analogs in the Coleus forskohlii, have the activity of activating cyclic AMP in vitro, and all of them can reduce intraocular pressure to different extent.
Function Of Coleus Forskohlii Extract
The Coleus forskohlii extract has a powerful antiasthmatic and antispasmodic effect. Its antispasmodic potency is 145 times that of aminophylline, but its toxicity is far less than that of aminophylline.
The Coleus forskohlii extracts, 1-acetoxyforskolin and isophorskolin, were shown to reduce blood pressure in anesthetized rats in a dose-dependent manner, there was no significant difference in heart rate and other parameters. It can inhibit ADP, and its mechanism may be related to the direct activation of adenoid cyclase by isoferskolin and the increase of cAMP level in platelets. The Coleus forskohlii extract has significant anti-tumor activity and can significantly increase the activity of adenylate cyclase and the accumulation of cAMP. The maintenance of cAMP level can effectively regulate cell proliferation and differentiation.
